Teri Hatcher = Susan Delfino
Felicia Huffman = Lynette Scavo
Marcia Cross = Bree Van de Kamp
Eva Longoria = Gabrielle „Gaby“ Solis
Ricardo Antonio Chavira = Carlos Solis
James Denton = Michael „Mike“ Delfino
Nicollette Sheridan = Edie Britt
Andrea Bowen = Julie Alexandra Mayer
Mark Moses = Paul Young
Cody Kasch = Zachary „Zach“ Young
Jesse Metcalfe = Jonathan „John“ Rowland
Steven Culp = Rex Van de Kamp
Doug Savant = Thomas „Tom“ Scavo
Richard Burgi = Karl Mayer
Alfre Woodard = Betty Applewhite
Kyle MacLachlan = Orson Hodge
Dana Delany = Katherine Mayfair
Shawn Pyfrom = Andrew Van de Kamp
Neal McDonough = David „Dave“ Williams
Maiara Walsh = Ana Solis
Drea de Matteo = Angela „Angie“ Bolen
Vanessa Williams = Renee Perry
Kathryn Joosten = Karen Bender
Kevin Rahm = Lee McDermott
Tuc Watkins = Bob Hunter
Madison De La Garza = Juanita Solis
Charles Mesure = Ben Faulkner
Jonathan Cake = Charles „Chuck“ Vance
Joy Lauren = Danielle Van de Kamp
Brent Kinsman = Preston Scavo
Shane Kinsman = Porter Scavo
Zane Huett Parker Scavo
Roger Bart = George Williams
Mehcad Brooks = Matthew Applewhite
NaShawn Kearse = Caleb Applewhite
Josh Henderson = Austin McCann
Rachel G. Fox = Kayla Huntington
Lyndsy Fonseca = Dylan Mayfair
Mason Vale = Cotton Maynard James „MJ“ Delfino
Jeffrey Nordling = Nick Bolen
Beau Mirchoff = Danny Bolen


Für weitere Gastrollen:
http://de.wikipedia.org/wiki/Desperate_Housewives#Besetzung